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Explore our interactive biosimilar news updates, collating tailored reports by brand, INN, originator/biosimilar applicant, litigation, region, or date. Alternatively, review our weekly BioBlast™ updates below.
Scientific Name: cetuximab

2022

AVEO Oncology and Eli Lilly enter into agreement for ficlatuzumab and cetuximab

June 22, 2022

AVEO Oncology announced that it has entered into a clinical trial collaboration and supply agreement with Eli Lilly to evaluate ficlatuzumab in combination with ERBITUX® (cetuximab) in the US and Canada in patients with recurrent or metastatic head and neck squamous cell carcinoma.  This follows a similar engagement with Merck earlier in 2022 regarding Aveo’s clinical development plan for ficlatuzumab.

First patients dosed in Biond Biologics trials for BND-22 (SAR444881) with pembrolizumab or cetuximab

May 23, 2022

Biond Biologics announced the first patients have been dosed in its Ph I trials of BND-22 (an Ig-Like Transcript 2 (ILT2) receptor blocking antibody) in combination with pembrolizumab or cetuximab being conducted in Israel and the US.  BND-22 is being developed under an exclusive world wide licence with Sanofi.

Study shows that levels of protein detected in head and neck tumours can be used to personalise patients’ medicine

March 28, 2022

Medical Xpress reports on an Institute of Cancer Research, London, study showing that levels of the protein PD-L1 detected in head and neck tumours can be used to personalise medicine.  Depending on PD-L1 levels, patients should receive personalised medicine of either chemotherapy with or without cetuximab, pembrolizumab in combination with chemotherapy, or pembrolizumab alone.

2021

US | FDA approves Erbitux® (cetuximab) in combination with Braftovi® (encorafenib) for metastatic colorectal cancer

September 28, 2021

Eli Lilly announced that the FDA has approved Erbitux® (cetuximab) in combination with Braftovi® (encorafenib) for the treatment of metastatic colorectal cancer with a BRAF V600E mutation.

New study indicates pembrolizumab in combination with cetuximab shows promise as treatment for head and neck squamous cell carcinoma

July 29, 2021

A new study published in Lancet Oncology reported that pembrolizumab in combination with cetuximab shows promise as a treatment for patients with recurrent or metastatic head and neck squamous cell carcinoma.

NKMax and Merck KGaA expand clinical trial and supply agreement

April 13, 2021

NKMax and Merck KGaA announced an expansion of its clinical trial and supply agreement to include a Ph I/IIa trial of SNK01 in combination with Erbitux® (cetuximab) in patients with locally advanced or metastatic non-small cell lung cancer.

US | FDA approves new dosage regimen for Erbitux® (cetuximab)

April 6, 2021

The FDA approved a new dosage regimen for Erbitux® (cetuximab) for patients with K-RAS wild-type, EGFR-expressing metastatic colorectal cancer or squamous cell carcinoma of the head and neck. The new dosage regimen allows for fortnightly dosing.

2020

AVEO reports data from Ph I study of ficlatuzumab and cetuximab

August 10, 2020

AVEO Oncology releases its Q2 FY2020 earnings report. AVEO reported data from its Ph I study of ficlatuzumab and cetuximab in patients with advanced head and neck squamous cell carcinoma (HNSCC) demonstrated that the products have an acceptable safety profile and showed promising anti-tumour activity in a refractory HNSCC patient population. AVEO also announced that it is evaluating the process to secure additional clinical manufacturing of ficlatuzumab to potentially enable a Ph III clinical trial in 2022.

FDA approves encorafenib/cetuximab combination

April 8, 2020

Pfizer announces the FDA has approved Braftovi® (encorafenib) in combination with Erbitux® (cetuximab) for the treatment of BRAF600E-mutant metastatic colorectal cancer after prior therapy.

2018

Pre-clinical study results of APZ 001

September 18, 2018

Researchers release results of pre-clinical study of cetuximab candidate APZ001. 

Amgen discloses cetuximab biosimilar under development

January 10, 2018

Amgen discloses at JP Morgan Healthcare Conference that it is in process development for a cetuximab biosimilar.

2016

MabTech announces successful Ph III trials of cetuximab

January 11, 2016

MabTech announces successful Chinese Ph III clinical trials for Sorrento’s “biosimilar/biobetter” cetuximab STI-001, and infliximab STI-002.

BioBlast® extract From January 11, 2016 to June 22, 2022